Methyl Acrylate → 3-(4-Formyl-3,5-dimethylphenyl)-acrylic acid methyl ester

Temperature

0 °C

The above 4-amino-2,6-dimethylbenzaldehyde (1.0 g, 6.71 mmol) was taken up in enough 42% HBF4 until the suspension stirred well and then was cooled to 0° C. A solution of NaNO2 (463 mg, 6.71 mmol) in water (5 mL) was added slowly and after 30 min at 0° C., MeOH (20 mL) was added followed by Pd(OAc)2 (229 mg) and methyl acrylate (1.16 g, 13.42 mmol). The reaction mixture was heated at 80° C. for 30 min then the suspension was filtered through Celite and washed with CH2Cl2. The combined organic layers were washed with water, brine, dried with MgSO4, and filtered. The solvent was removed under reduced pressure and the residue was purified by flash chromatography using a 10/1 to 5/1 gradient of heptane/EtOAc to give 3-(4-formyl-3,5-dimethylphenyl)-acrylic acid methyl ester as a light yellow solid.

1. temperatureThe reaction mixture was heated at 80° C. for 30 min
2. filtrationthe suspension was filtered through Celite
3. washwashed with CH2Cl2
4. washThe combined organic layers were washed with water, brine
5. dry with materialdried with MgSO4
6. filtrationfiltered
7. customThe solvent was removed under reduced pressure
8. customthe residue was purified by flash chromatography

ORD record

ord-27ce6b507a7749ec95df1b07cd2f05b4

Source dataset

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08222248B2