Potassium Carbonate → HCID 66937650, compound

HRID 1515365Notes

Reaction equation

HRID 1515365 reaction equation
C([O:4][CH2:5][C:6]1[S:7][C:8]2[C:13]([C:14](=[O:17])[C:15]=1[I:16])=[CH:12][CH:11]=[CH:10][CH:9]=2)(=O)C.C(=O)([O-])[O-].[K+].[K+].[Cl-].[NH4+]>CO>[OH:4][CH2:5][C:6]1[S:7][C:8]2[C:13]([C:14](=[O:17])[C:15]=1[I:16])=[CH:12][CH:11]=[CH:10][CH:9]=2

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 25517Ammonium ChlorideHCID 66937663HCID 66937663, compound

Product 1

HCID 66937650HCID 66937650, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound (0.027 mmol, 10 mg) obtained in (1) above was dissolved in methanol, to which potassium carbonate (0.015 mmol, 2.05 mg) was added at 0° C., and the resulting solution was stirred for 1 hour. After the disappearance of the starting materials was confirmed by thin-layer chromatography, a saturated aqueous ammonium chloride solution was added to the reaction solution to terminate the reaction. Then, extraction was performed with methylene chloride, the obtained organic layer was dried over sodium sulfate, and the solvents were evaporated under reduced pressure. The residue was purified by silica gel column chromatography, and the title compound (0.019 mmol, 6.2 mg) was obtained in a 72% yield.

Workup

  1. additionwas added at 0° C.
  2. customto terminate
  3. customthe reaction
  4. extractionThen, extraction
  5. dry with materialthe obtained organic layer was dried over sodium sulfate
  6. customthe solvents were evaporated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-8c1da4b475ba4300a436f07ce45b4adf
Source dataset
uspto-grants-2012_07
Patent number
US08222429B2

Reaction notes

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