Hydrochloric Acid → 2-(Hydroxymethyl)-5-mercapto-4(1h)-pyridinol hydrochloride salt

HRID 15161Notes

Reaction equation

C([O:4][CH2:5][C:6]1[NH:7][CH:8]=[C:9]([S:13]C(C)(C)C)[C:10](=[O:12])[CH:11]=1)(=O)C.[ClH:18]>>[ClH:18].[OH:4][CH2:5][CH:6]1[CH:11]=[C:10]([OH:12])[C:9]([SH:13])=[CH:8][NH:7]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 67526579{5-[(1,1-Dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate

Product 1

HCID 866141532-(Hydroxymethyl)-5-mercapto-4(1h)-pyridinol hydrochloride salt

Conditions

Temperature: 80 °C

Procedure

A mixture of {5-[(1,1-dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate (240 mg, 0.94 mmol) and concentrated hydrochloric acid (2 ml) was heated to 80° C. overnight. The solvent was evaporated affording a pale yellow solid.

Workup

customThe solvent was evaporated
customaffording a pale yellow solid

Sources & evidence

ORD record: ord-9a5726d044784afe8533dfb5fa5b7ab4
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732460B2

Reaction notes

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