反应详情

Palladium (II) hydroxide (100 mg) was added to a solution of the nitro compound of step 3 (970 mg, 3.39 mmol) in methanol (20 mL) and the mixture warmed to reflux. Ammonium formate (1.07 g, 16.97 mmol) was added and the reaction mixture stirred at reflux for 2 hours. The catalyst was removed by filtration through Arbocel® and the reaction mixture concentrated in vacuo to yield the amide product.

1. temperaturethe mixture warmed to reflux
2. temperatureat reflux for 2 hours
3. customThe catalyst was removed by filtration through Arbocel®
4. concentrationthe reaction mixture concentrated in vacuo