Hydrochloric Acid → HCID 25271233, compound

HRID 1516409Notes

Reaction equation

HRID 1516409 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([S:27]([CH3:38])(=[N:29][C:30](=[O:37])[CH2:31][N:32]([CH2:35][CH3:36])[CH2:33][CH3:34])=[O:28])=[CH:23][CH:22]=2)=[O:20])=[O:10])=[N:6][CH:7]=1.Cl>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([S:27]([CH3:38])(=[N:29][C:30](=[O:37])[CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36])=[O:28])=[CH:23][CH:22]=2)=[O:20])=[O:10])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25269170HCID 25269170, compound

Product 1

HCID 25271233HCID 25271233, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diethylamino-acetyl)sulfoximide (200 mg,0.3478 mmol) in DCM (5mL) was added 12% ethereal hydrochloric acid solution (115 mg,0.3826 mmol) at 10-15° C. After one hour, solvent was concentrated and product was stirred in ether. Filteration afforded 90 mg of desired product in 42% yield.

Workup

  1. concentrationsolvent was concentrated

Sources & evidence

ORD record
ord-0dfd0a5b420046119fcb0f9ede613fe0
Source dataset
uspto-grants-2012_07
Patent number
US08227492B2

Reaction notes

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