反应详情

To a solution of 2-(3-cyano-4-phenylpyrrole-1-yl)-5-hydroxyisonicotinic acid ethyl ester (0.050 g) in a mixed solvent of tetrahydrofuran (3.6 mL) and ethanol (1.2 mL) was added 1 mol/L aqueous lithium hydroxide solution (1.2 mL) at room temperature, and this mixture was stirred at same temperature for 5 hours. This mixture was poured into water, this mixture was washed with diethyl ether. To this aqueous layer was added 1 mol/L hydrochloric acid (1.2 mL), and the precipitated solid was collected by filtration, and washed with water and n-hexane. This solid was dried under reduced pressure at 50° C. to give the title compound (0.030 g).

1. washthis mixture was washed with diethyl ether
2. additionTo this aqueous layer was added 1 mol/L hydrochloric acid (1.2 mL)
3. filtrationthe precipitated solid was collected by filtration
4. washwashed with water and n-hexane
5. customThis solid was dried under reduced pressure at 50° C.