反应详情

温度

50 °C

3-Cyanophenol (10.1 g, 84.8 mmol) and potassium carbonate (19.5 g, 141 mmol) were suspended in acetone (280 ml), 2-bromoethyl acetate (7.8 ml, 70.7 mmol) was added, and the mixture was stirred at 50° C. for 8 hours. Sodium iodide (1.06 g, 7.07 mmol) was added to the reaction mixture, and the mixture was heated under reflux for two nights and concentrated under reduced pressure. The residue was diluted with ethyl acetate, and the mixture was washed with 1N sodium hydroxide, 1N hydrochloric acid, and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound without purification.

1. temperaturethe mixture was heated
2. temperatureunder reflux for two nights
3. concentrationconcentrated under reduced pressure
4. additionThe residue was diluted with ethyl acetate
5. washthe mixture was washed with 1N sodium hydroxide, 1N hydrochloric acid, and saturated brine
6. dry with materialdried over anhydrous sodium sulfate
7. customThe solvent was evaporated under reduced pressure