反应详情

1-tert-Butyl 4-ethyl 4-methylpiperidine-1,4-dicarboxylate (500 mg, 1.84 mmol) obtained in Step 1 was dissolved in 4N hydrochloric acid/1,4-dioxane (4 ml), and the mixture was stirred at room temperature for 30 minutes. The solvent was evaporated under reduced pressure, and the obtained residue was dissolved in ethanol (18.4 ml). 4-Chloropyridine hydrochloride (276 mg, 1.84 mmol) and triethylamine (2.57 ml, 18.4 mmol) were added thereto, and the reaction mixture was stirred at 170° C. overnight in a sealed tube. The mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel chromatography (hexane:ethyl acetate 95:5-10:90) to give the title compound.

1. customThe solvent was evaporated under reduced pressure
2. dissolutionthe obtained residue was dissolved in ethanol (18.4 ml)
3. stirringthe reaction mixture was stirred at 170° C. overnight in a sealed tube
4. concentrationThe mixture was concentrated under reduced pressure
5. customthe obtained residue was purified by silica gel chromatography (hexane:ethyl acetate 95:5-10:90)