Tetrahydrofuran → N-[5-tert-butyl-3-[(1-hydroxycyclobutyl)methyl]-1,3-thiazol-2-ylidene]-2-methoxy-5-(trifluoromethyl)benzamide

HRID 151684Notes

Reaction equation

HRID 151684 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][n:7]([CH2:11][C:12]2([OH:16])[CH2:13][CH2:14][CH2:15]2)[c:8](=[NH:10])[s:9]1.[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:17][O:18][c:19]1[c:20]([C:21](=[O:22])[OH:23])[cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]1.[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[S:32]([Cl:33])([Cl:34])=[O:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][n:7]([CH2:11][C:12]2([OH:16])[CH2:13][CH2:14][CH2:15]2)[c:8](=[N:10][C:21]([c:20]2[c:19]([O:18][CH3:17])[cH:27][cH:26][c:25]([C:28]([F:29])([F:30])[F:31])[cH:24]2)=[O:22])[s:9]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 135859092-Methoxy-5-(trifluoromethyl)benzoic acidHCID 668520141-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)cyclobutanol

Product 1

HCID 66852168N-[5-tert-butyl-3-[(1-hydroxycyclobutyl)methyl]-1,3-thiazol-2-ylidene]-2-methoxy-5-(trifluoromethyl)benzamide

Sources & evidence

ORD record
ord-c03767e1a001462ba7015a718af6432a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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