Hydrochloric Acid → Creatine Monohydrate

Temperature

75 °C

4625 g (16.7 mol) of a 40% by weight sodium sarcosinate solution prepared according to example 1 was added first. A pH of 9.6 (at 20° C.) was adjusted using concentrated hydrochloric acid while cooling externally with cold water and stirring vigorously. Subsequently it was heated to 75° C. 1403 g (16.7 mol) of a 50% by weight aqueous cyanamide solution (Degussa-Cyanamide L 500) was added uniformly over a period of 90 minutes while stirring vigorously at an internal temperature of 75 to 80° C. After the cyanamide addition was completed, the reaction mixture was stirred for a further 2 hours at an internal temperature of 75° C. After cooling to 5° C., the crystalline reaction product that can be readily filtered was suction filtered, washed three times chloride-free with 1250 ml water in each case and dried in a vacuum-drying cabinet at 40° C. and 20 mbar. The yield was 1897 g creatine monohydrate (corresponds to a yield of 76.2% of theory).

1. additionwas added first
2. customA pH of 9.6 (at 20° C.)
3. stirringwhile stirring vigorously at an internal temperature of 75 to 80° C
4. stirringthe reaction mixture was stirred for a further 2 hours at an internal temperature of 75° C
5. temperatureAfter cooling to 5° C.
6. filtrationthe crystalline reaction product that can be readily filtered
7. filtrationfiltered
8. washwashed three times chloride-free with 1250 ml water in each case
9. customdried in a vacuum-drying cabinet at 40° C.

ORD record

ord-8fc661d9bcad4b2bb722dc5021c98177

Source dataset

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08227638B2