Ammonium Chloride → HCID 59504882, compound

A solution of 4-acetylbenzonitrile (13.2 g, 90.9 mmol) in anhydrous tetrahydrofuran (100 mL) was cooled to −70° C. under nitrogen and sodium bis(trimethylsilyl)amide solution (1.0 M in THF, 100 mL, 100 mmol) added dropwise over 30 minutes. The solution was stirred at −70° C. for 1 hour before di-tert-butyl oxalate (22.1 g, 109 mmol) was added. The resulting suspension allowed to warm to room temperature and stir for 16 hours. The suspension was poured onto water (250 mL) containing ammonium chloride (53.5 g, 1.0 mol) and extracted with ethyl acetate (100 mL+50 mL). The organic layer was washed with water (100 mL) and concentrated under reduced pressure to afford a dark solid residue. The residue was triturated with diethyl ether (130 mL) and the residue filtered and dried under reduced pressure to give the title compound as a brown solid (7.13 g, 29%). 1H NMR (400 MHz, CDCl3): δ 1.40 (9 H, s), 7.01 (1 H, br), 8.01-8.23 (4 H, m).

1. additionwas added
2. additionThe suspension was poured onto water (250 mL)
3. extractionextracted with ethyl acetate (100 mL+50 mL)
4. washThe organic layer was washed with water (100 mL)
5. concentrationconcentrated under reduced pressure
6. customto afford a dark solid residue
7. customThe residue was triturated with diethyl ether (130 mL)
8. filtrationthe residue filtered
9. customdried under reduced pressure

ORD record

ord-8c2ae7f64cdd4ff6bdb3496c446dc01e

Source dataset

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08232269B2