反应详情

Sodium hydride (12 mg of a 60% of a dispersion in mineral oil, 0.3 mmol) was added to isopropanol (5 ml). The mixture was stirred at room temperature for 10 minutes. Then, 2,4-dichloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine (60 mg, 0.2 mmol) was added to this solution. The resulting mixture was stirred at room temperature for another 40 minutes. After concentration under reduced pressure, the residue was purified by silica gel flash chromatography, the mobile phase being a mixture of isopropanol and dichloromethane in a volume ratio of 1:200, yielding the pure title compound (21 mg, yield 30%) as a white solid which was characterised as follows: MS (m/z): 318 ([M+H]+, 100).

1. stirringThe resulting mixture was stirred at room temperature for another 40 minutes
2. concentrationAfter concentration under reduced pressure
3. customthe residue was purified by silica gel flash chromatography
4. additiona mixture of isopropanol and dichloromethane in a volume ratio of 1:200