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Finely ground potassium carbonate (41.1 g) is added to a stirred dioxane solution of Octyl alcohol (36.9 g) cooled by an ice bath followed by addition over approximately 15 minutes of 2-bromoacetyl bromide (40.0 g). The mixture is stirred overnight, filtered and the dioxane is removed under vacuum. The residue is taken up in dichloromethane, washed with 10% HCl, water, sodium bicarbonate, and dried over magnesium sulfate. After removal of the solvent, the product is obtained as a light yellow oil.

1. temperaturecooled by an ice bath
2. filtrationfiltered
3. customthe dioxane is removed under vacuum
4. washwashed with 10% HCl, water, sodium bicarbonate
5. dry with materialdried over magnesium sulfate
6. customAfter removal of the solvent
7. customthe product is obtained as a light yellow oil