Hydrochloric Acid → HCID 69812891, compound

HRID 1517525Notes

Reaction equation

HRID 1517525 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:21])[C@H:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[C:14]([CH3:20])=[N:15][N:16]([CH3:19])[C:17]=3[CH3:18])[CH:11]=2)[CH2:6][CH2:5]1>C(OCC)(=O)C>[ClH:1].[CH3:21][N:3]([CH3:2])[C@H:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[C:14]([CH3:20])=[N:15][N:16]([CH3:19])[C:17]=3[CH3:18])[CH:11]=2)[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58173142HCID 58173142, compound

Product 1

HCID 69812891HCID 69812891, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

HCl (0.9 mmol, 2 M solution in Et2O) was dropwise added to a solution of (R)-dimethyl-[6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-indan-1-yl]-amine (1 mmol) in ethyl acetate. The reaction mixture was stirred at room temperature for 30 min and then the solvent was concentrated off. The resulting solid was suspended in acetone and the precipitate formed was collected by filtration, washed with acetone and vacuum dried, giving the title compound as a white solid (75%).

Workup

  1. concentrationthe solvent was concentrated off
  2. customthe precipitate formed
  3. filtrationwas collected by filtration
  4. washwashed with acetone and vacuum
  5. customdried

Sources & evidence

ORD record
ord-bddf33364039444f948bf3f6d03a222e
Source dataset
uspto-grants-2012_07
Patent number
US08232307B2

Reaction notes

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