Hydrochloric Acid → HCID 69811879, compound

HRID 1517526Notes

Reaction equation

HRID 1517526 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:21])[C@H:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[C:14]([CH3:20])=[N:15][N:16]([CH3:19])[C:17]=3[CH3:18])[CH:11]=2)[CH2:6][CH2:5]1>C(OCC)(=O)C>[ClH:1].[ClH:1].[CH3:21][N:3]([CH3:2])[C@H:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[C:14]([CH3:20])=[N:15][N:16]([CH3:19])[C:17]=3[CH3:18])[CH:11]=2)[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58173142HCID 58173142, compound

Product 1

HCID 69811879HCID 69811879, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

HCl (2.1 mmol, 2 M solution in Et2O) was dropwise added to a solution of (R)-dimethyl-[6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-indan-1-yl]-amine (1 mmol) in ethyl acetate. The reaction mixture was stirred at room temperature for 30 min and then the solvent was concentrated off. The resulting solid was suspended in Et2O and concentrated, in order to remove excess of HCl. This operation was done for three times, to give the title product (white solid, 98% yield).

Workup

  1. concentrationthe solvent was concentrated off
  2. concentrationconcentrated, in order
  3. customto remove excess of HCl

Sources & evidence

ORD record
ord-4c0fcb1e46904f2cb240f255b7cc32dc
Source dataset
uspto-grants-2012_07
Patent number
US08232307B2

Reaction notes

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