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step 2—To a solution of 78 (109 mg, 0.26 mmol) in MeOH (7 mL) and THF (1 mL) was added 20% Pd(OH)2/C (wet, 20 mg). The reaction mixture was stirred under an atmosphere of hydrogen (balloon) for 2 h then filtered through a pad of CELITE, rinsing with EtOAc. The filtrate was concentrated under reduced pressure to afford 79 mg (93%) of I-54 as an off-white solid: MS=330 [M+H]+.

1. filtrationthen filtered through a pad of CELITE
2. washrinsing with EtOAc
3. concentrationThe filtrate was concentrated under reduced pressure
4. customto afford 79 mg (93%) of I-54 as an off-white solid