反应详情

To a solution of (R)-1-(4-(4-(7-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-2,3-dihydro-5-methyl-3-oxo-2-phenylpyrazol-1-yl)propan-2-yl 2-(dimethylamino)acetate (100 mg, 0.16 mmol) in a mixture of MeOH (10 mL)/EtOAc (15 mL) was added a saturated solution of HCl in EtOAc (5 mL). After stirring for 40 minutes, the resulted mixture was concentrated in vacuo. The residue was recrystallized in a mixture of MeOH (2 mL)/EtOAc (8 mL). The solid was collected by filtration, washed with EtOAc (5 mL×3) and dried under vacuum overnight. The title compound was obtained as a yellow solid (90.1 mg, 80%).

1. concentrationthe resulted mixture was concentrated in vacuo
2. customThe residue was recrystallized in a mixture of MeOH (2 mL)/EtOAc (8 mL)
3. filtrationThe solid was collected by filtration
4. washwashed with EtOAc (5 mL×3)
5. customdried under vacuum overnight