HRID1517866

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCCC5(OC(=O)CNC(=O)OC(C)(C)C)CC5)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C

HCID66693891

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCCC5(OC(=O)CN)CC5)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C.Cl

HCID66693381

未命名化合物

收率 30.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

To a solution of 1-(2-(4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)quinolin-7-yloxy)ethyl)cyclopropyl 2-(tert-butoxy-carbonylamino)acetate (190 mg, 0.262 mmol) in 8 mL of ethyl acetate was added a solution of HCl in EtOAc (0.93 mol/L, 5 mL) dropwise. The reaction mixture was stirred at rt for 30 minutes and then filtered. The solid was washed with ethyl acetate (20 mL×3) to afford the title compound as a white solid (54 mg, 30.3%).

WORKUP

后处理

filtrationfiltered
washThe solid was washed with ethyl acetate (20 mL×3)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1b45e45b0be47f7b23f2cbae525ea7e
来源数据集: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08232294B2
来源说明: uspto-grants-2012_07

反应 SMILES

C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1([CH2:16][CH2:17][O:18][C:19]2[CH:28]=[C:27]3[C:22]([C:23]([O:29][C:30]4[CH:35]=[CH:34][C:33]([NH:36][C:37]([C:39]5[C:40](=[O:52])[N:41]([C:46]6[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=6)[N:42]([CH3:45])[C:43]=5[CH3:44])=[O:38])=[CH:32][C:31]=4[F:53])=[CH:24][CH:25]=[N:26]3)=[CH:21][CH:20]=2)[CH2:15][CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:54]>C(OCC)(=O)C>[ClH:54].[NH2:8][CH2:9][C:10]([O:12][C:13]1([CH2:16][CH2:17][O:18][C:19]2[CH:28]=[C:27]3[C:22]([C:23]([O:29][C:30]4[CH:35]=[CH:34][C:33]([NH:36][C:37]([C:39]5[C:40](=[O:52])[N:41]([C:46]6[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=6)[N:42]([CH3:45])[C:43]=5[CH3:44])=[O:38])=[CH:32][C:31]=4[F:53])=[CH:24][CH:25]=[N:26]3)=[CH:21][CH:20]=2)[CH2:15][CH2:14]1)=[O:11]