Hydrochloric Acid → (S)-((R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate hydrochloride

HRID 1517888Notes

Reaction equation

HRID 1517888 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([C:25]2[C:26](=[O:46])[N:27]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[N:28]([CH2:31][C@H:32]([O:34][C:35](=[O:39])[C@@H:36]([NH2:38])[CH3:37])[CH3:33])[C:29]=2[CH3:30])=[O:24])=[CH:18][C:17]=1[F:47].[ClH:48]>CCOC(C)=O>[ClH:48].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([C:25]2[C:26](=[O:46])[N:27]([C:40]3[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:28]([CH2:31][C@H:32]([O:34][C:35](=[O:39])[C@@H:36]([NH2:38])[CH3:37])[CH3:33])[C:29]=2[CH3:30])=[O:24])=[CH:18][C:17]=1[F:47]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66669905HCID 66669905, compound

Product 1

HCID 66669904(S)-((R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Example 1 Step 3 by using (S)—((R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl-carbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate (165.3 mg, 0.257 mmol) and a saturated HCl solution in EtOAc (5 mL). The title compound was obtained as a pale yellow solid (160 mg, 87%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-d312f5db9a7d43e6b760dd9afd9ab837
Source dataset
uspto-grants-2012_07
Patent number
US08232294B2

Reaction notes

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