Hydrochloric Acid → HCID 66670757, compound

HRID 1517889Notes

Reaction equation

HRID 1517889 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:13][C:14]3[CH:15]=[CH:16][C:17]([NH:20][C:21]([C:23]4[C:24](=[O:50])[N:25]([C:44]5[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=5)[N:26]([CH2:29][C@H:30]([O:32][C:33](=[O:43])[CH2:34][NH:35]C(OC(C)(C)C)=O)[CH3:31])[C:27]=4[CH3:28])=[O:22])=[N:18][CH:19]=3)=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.[ClH:51]>CCOC(C)=O>[ClH:51].[NH2:35][CH2:34][C:33]([O:32][C@H:30]([CH3:31])[CH2:29][N:26]1[C:27]([CH3:28])=[C:23]([C:21](=[O:22])[NH:20][C:17]2[CH:16]=[CH:15][C:14]([O:13][C:7]3[C:6]4[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=4)[N:10]=[CH:9][CH:8]=3)=[CH:19][N:18]=2)[C:24](=[O:50])[N:25]1[C:44]1[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1)=[O:43]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68739574HCID 68739574, compound

Product 1

HCID 66670757HCID 66670757, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Example 1 Step 3 by using (R)-1-(4-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-ylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl2-(tert-butoxycarbonyl amino)acetate (100 mg, 0.146 mmol) and a saturated HCl solution in EtOAc (3 mL). The title compound was crystallized in MeOH/EtOAc (20 mL, v/v=1:5) to afford the title compound as a white solid (84.2 mg, 76%).

Workup

  1. customThe title compound was prepared
  2. customThe title compound was crystallized in MeOH/EtOAc (20 mL, v/v=1:5)

Sources & evidence

ORD record
ord-970c93a5c29447568d8d1659f2e68e6c
Source dataset
uspto-grants-2012_07
Patent number
US08232294B2

Reaction notes

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