Hydrochloric Acid → HCID 66669811, compound

HRID 1517917Notes

Reaction equation

HRID 1517917 reaction equation
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1([CH2:16][CH2:17][O:18][C:19]2[CH:28]=[C:27]3[C:22]([C:23]([O:29][C:30]4[CH:35]=[CH:34][C:33]([NH:36][C:37]([C:39]5([C:42](=[O:50])[NH:43][C:44]6[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=6)[CH2:41][CH2:40]5)=[O:38])=[CH:32][C:31]=4[F:51])=[CH:24][CH:25]=[N:26]3)=[CH:21][CH:20]=2)[CH2:15][CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:52]>CCOC(C)=O>[ClH:52].[NH2:8][CH2:9][C:10]([O:12][C:13]1([CH2:16][CH2:17][O:18][C:19]2[CH:28]=[C:27]3[C:22]([C:23]([O:29][C:30]4[CH:35]=[CH:34][C:33]([NH:36][C:37]([C:39]5([C:42](=[O:50])[NH:43][C:44]6[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=6)[CH2:40][CH2:41]5)=[O:38])=[CH:32][C:31]=4[F:51])=[CH:24][CH:25]=[N:26]3)=[CH:21][CH:20]=2)[CH2:14][CH2:15]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66669760HCID 66669760, compound

Product 1

HCID 66669811HCID 66669811, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropane-carboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl 2-(tert-butoxycarbonylamino)acetate (23 mg, 0.03 mmol) in EtOAc (1 mL) was added HCl (2 mol/L in EtOAc, 1 mL). The mixture was stirred at rt for 2 h, and then concentrated in vacuo to give the title compound as a white solid (15 mg, 83%).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-da038c80bfdb43fca449aa28e500cdfc
Source dataset
uspto-grants-2012_07
Patent number
US08232294B2

Reaction notes

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