Water → HCID 59334950, compound

HRID 1517939Notes

Reaction equation

HRID 1517939 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][CH2:17][CH2:16]3)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[C:36](Cl)(=[O:43])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1.O>ClCCl>[C:36]([N:18]1[C:19]2[C:15](=[CH:14][C:13]([N:12]([CH2:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[S:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)(=[O:11])=[O:10])=[CH:21][CH:20]=2)[CH2:16][CH2:17]1)(=[O:43])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7412Benzoyl chlorideHCID 11430Potassium CarbonateHCID 59334895HCID 59334895, compound

Product 1

HCID 59334950HCID 59334950, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

150 mg tert.butyl [(3,5-dichloro-phenylsulphonyl)-(2,3-dihydro-1H-indol-5-yl)-amino]-acetate are dissolved in 5 ml dichloromethane. 110 mg potassium carbonate and 45 μl benzoyl chloride are added, the mixture is stirred for 3 hours at ambient temperature and then divided between dichloromethane and water. The organic phase is washed with water and then dried on magnesium sulphate. The solvents are eliminated in vacuo.

Workup

  1. washThe organic phase is washed with water
  2. customdried on magnesium sulphate

Sources & evidence

ORD record
ord-6802d6dcd4e14ab7bbe5885bd58bce19
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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