Sodium Hydroxide → HCID 59335126, compound

HRID 1517958Notes

Reaction equation

HRID 1517958 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17]([C:22]([O:24]CC)=[O:23])=[CH:16]3)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+]>O1CCCC1.O.Cl>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17]([C:22]([OH:24])=[O:23])=[CH:16]3)(=[O:10])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 59335063HCID 59335063, compound

Product 1

HCID 59335126HCID 59335126, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

100 mg ethyl 5-(3,5-dichloro-phenylsulphonylamino)-1H-indole-2-carboxylate are dissolved in 2 ml of tetrahydrofuran and combined with 2 ml of 1 N sodium hydroxide solution. The mixture is stirred for 48 hours at ambient temperature, the tetrahydrofuran is eliminated in vacuo, the residue is diluted with water, and 1 N hydrochloric acid is added until the pH is 2. The precipitated solid is suction filtered, washed with water and dried in vacuo.

Workup

  1. additionis added until the pH is 2
  2. filtrationfiltered
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-0eca610fa4ce47aca70ea9b7abecc193
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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