HCID 59335099, compound → HCID 59335142, compound

HRID 1517977Notes

Reaction equation

HRID 1517977 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:10]([N:13]([CH2:29][C:30]([OH:32])=[O:31])[C:14]2[CH:15]=[CH:16][C:17]3[N:18]([CH2:27][CH3:28])[C:19]4[C:24]([C:25]=3[CH:26]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)(=[O:12])=[O:11])[CH:5]=[C:6]([C:8]#[CH:9])[CH:7]=1.[H][H]>C(OCC)(=O)C.[Pt](=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([S:10]([N:13]([CH2:29][C:30]([OH:32])=[O:31])[C:14]2[CH:15]=[CH:16][C:17]3[N:18]([CH2:27][CH3:28])[C:19]4[C:24]([C:25]=3[CH:26]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)(=[O:12])=[O:11])[CH:5]=[C:6]([CH2:8][CH3:9])[CH:7]=1

Participants

5

Reactant 2

HCID 59335099HCID 59335099, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59335142HCID 59335142, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 8857Ethyl AcetateSolvent

Procedure

104 mg [(3-chloro-5-ethynyl-phenylsulphonyl)-(9-ethyl-9H-carbazol-3-yl)-amino]-acetic acid are dissolved in 5 ml of ethyl acetate. 30 mg of platinum dioxide are added and the mixture is hydrogenated for 5.5 hours at 3 bar hydrogen pressure. Then the catalyst is removed by suction filtering, the solvent is eliminated in vacuo and the residue is purified by preparative HPLC.

Workup

  1. customThen the catalyst is removed by suction
  2. filtrationfiltering
  3. customthe residue is purified by preparative HPLC

Sources & evidence

ORD record
ord-ae06f466f7b84fecafc415cb64af8e22
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

Loading…