反应详情

温度

100 °C

A Vilsmeier reagent prepared from DMF (23 mL) and phosphoryl chloride (78.4 mL) at 0-10° C. is slowly added dropwise to 3-fluoroacetanilide (18.5 g, 0.12 mol) and the resulting mixture is stirred at 100° C. for 14 hours. The mixture is poured onto ice-water and extracted with CH2Cl2 twice. The combined organic layer is dried, filtered and concentrated. The crystal is collected and washed with CH2Cl2 to give 2-chloro-7-fluoroquinoline-3-carbaldehyde as a brown powder.

1. additionThe mixture is poured onto ice-water
2. extractionextracted with CH2Cl2 twice
3. customThe combined organic layer is dried
4. filtrationfiltered
5. concentrationconcentrated
6. customThe crystal is collected
7. washwashed with CH2Cl2