反应详情

A solution of (3-nitro-phenyl)-acetonitrile (11.4 g, 70.4 mmol) in THF (100 ml) was heated to reflux and borane dimethylsulfide (2M in THF, 77.34 mmol) was added. The mixture was stirred for 2 h under reflux. After complete conversion the mixture was allowed to come to room temperature and a solution of HCl in ethanol (1M) was added. After stirring the mixture for 30 min it was concentrated under reduced pressure. The residue was triturated with diethylether, filtered, washed with diethylether and dried in vacuo to give the product as a yellow powder (13.1 g, 92%).

1. temperatureto reflux
2. temperatureunder reflux
3. customto come to room temperature
4. stirringAfter stirring the mixture for 30 min it
5. concentrationwas concentrated under reduced pressure
6. customThe residue was triturated with diethylether
7. filtrationfiltered
8. washwashed with diethylether
9. customdried in vacuo