Water → HCID 67132523, compound

HRID 1518206Notes

Reaction equation

HRID 1518206 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21](O)=[O:22])=[CH:16][CH:15]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].CN(C)C=O.[CH2:29]([NH2:32])[CH2:30][CH3:31].O>N1C=CC=CC=1>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([CH2:20][C:21]([NH:32][CH2:29][CH2:30][CH3:31])=[O:22])=[CH:18][CH:19]=2)(=[O:11])=[O:12])=[CH:6][CH:5]=1)([CH3:2])[CH3:3]

Participants

6

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 7852PropylamineHCID 67132848HCID 67132848, compound

Product 1

HCID 67132523HCID 67132523, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of [4-(4-isopropyl-benzenesulfonylmethyl)-phenyl]-acetic acid (1 g, 3.00 mmol) in pyridine (15 ml)/N,N-dimethylformamide (15 ml) N,N′-carbonyldiimidazole (0.54 g, 3.31 mmol) was added and the mixture heated to 50° C. for 1 h. At 0° C. propylamine was added. The mixture was stirred at room temperature for 16 h. Then, the mixture was poured into water. The precipitate was collected and dried in a vacuum oven at 70° C. to give the product as a yellow powder (0.89 g, 2.39 mmol).

Workup

  1. customThe precipitate was collected
  2. customdried in a vacuum oven at 70° C.

Sources & evidence

ORD record
ord-cea698ef951f48ccb94e25314f3f4443
Source dataset
uspto-grants-2012_07
Patent number
US08232426B2

Reaction notes

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