反应详情

(2-Bromo-5-methoxyphenyl)methanol (1 eq.) was dissolved in anhydrous DMF (1.1M solution) and imidazole (1.05 eq.) was added. To the stirred solution triisopropylsilyl chloride (1.1 eq.) was added and the resulting mixture was left stirring at RT for 8 h. All volatiles were evaporated in vacuo and the residual material was filtered with PE/EtOAc (9:1) over a pad of silica gel. After evaporation in vacuo the product was obtained as a colorless oil (94%), which was used without further characterization in the next reaction.

1. waitthe resulting mixture was left
2. customAll volatiles were evaporated in vacuo
3. filtrationthe residual material was filtered with PE/EtOAc (9:1) over a pad of silica gel
4. customAfter evaporation in vacuo the product