反应详情

温度

0 °C

To a solution of compound 21C (100 mg, 0.31 mmol) in THF (5 mL) was added NaOH (0.248 mL, 0.621 mmol) and hydrogen peroxide (0.048 mL, 0.466 mmol). The mixture was stirred at 0° C. for 30 minutes. The reaction mixture was concentrated under reduced pressure and the concentrate was dissolved in 8 mL of water. The aqueous solution was acidified with diluted HCl. A white precipitate was collected, washed with water, and dried to provide the desired product 21D: 1H NMR (400 MHz, DMSO-D6) δ ppm 9.75 (1H, s), 9.44 (1H, s), 9.09 (1H, s), 8.59 (1H, s), 7.82-7.99 (2H, m), 6.83-7.05 (2H, m).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. dissolutionthe concentrate was dissolved in 8 mL of water
3. customA white precipitate was collected
4. washwashed with water
5. customdried