Hydrochloric Acid → HCID 59447532, compound

HRID 1518339Notes

Reaction equation

HRID 1518339 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][C:4]#[C:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]COCC[Si](C)(C)C)=[CH:8][N:7]=1.Cl.CCOCC>CO>[CH3:21][N:2]([CH3:1])[CH2:3][C:4]#[C:5][C:6]1[N:7]=[CH:8][C:9]([OH:12])=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59447599HCID 59447599, compound

Product 1

HCID 59447532HCID 59447532, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 57B (40 mg, 0.131 mmol) in MeOH (3 ml) was treated with 2 N hydrogen chloride in ether (0.1 ml, 0.200 mmol) for 1 h and the mixture was concentrated to provide the title compound 57C. LCMS (APCI) m/e 177 (M+H).

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-fba4d7d9315c49bb8691e20fbfe59f61
Source dataset
uspto-grants-2012_07
Patent number
US08232273B2

Reaction notes

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