Ammonium Hydroxide → 3-Cyano-4-fluorobenzene-1-sulfonamide

HRID 1518805Notes

Reaction equation

HRID 1518805 reaction equation
[OH-].[NH4+:2].[C:3]([C:5]1[CH:6]=[C:7]([S:12](Cl)(=[O:14])=[O:13])[CH:8]=[CH:9][C:10]=1[F:11])#[N:4]>Cl>[C:3]([C:5]1[CH:6]=[C:7]([S:12]([NH2:2])(=[O:14])=[O:13])[CH:8]=[CH:9][C:10]=1[F:11])#[N:4]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 27789083-Cyano-4-fluorobenzenesulfonyl chloride

Product 1

HCID 251398973-Cyano-4-fluorobenzene-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Concentrated ammonium hydroxide (28% solution in water, 3.17 mL) was cooled to 0° C. and 3-cyano-4-fluorobenzene-1-sulfonyl chloride (1.00 g) was added. The solution was mixed at 0° C. for four minutes. 4M HCl (10 mL) was added slowly and the solution was extracted with ethyl acetate. The extract was dried on brine and anhydrous sodium sulfate and the solvent removed under vacuum.

Workup

  1. additionThe solution was mixed at 0° C. for four minutes
  2. extractionthe solution was extracted with ethyl acetate
  3. dry with materialThe extract was dried on brine and anhydrous sodium sulfate
  4. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-bd62ae965b8c4774b5958da14af5f775
Source dataset
uspto-grants-2015_07
Patent number
US09072748B2

Reaction notes

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