反应详情

温度

70 °C

To a pressure reaction flask containing compound 7A (1.5 g, 7.2 mmol) in THF (30 mL) were added 1,2-ethanedithiol (2.4 g, 28.6 mmol) and NaBH (812 mg, 21.5 mmol). It was sealed, and heated at 70° C. for 2 hr, and cooled to RT. The reaction mixture was concentrated, dissolved in EtOAc, washed with water, dried over Na2SO4, and concentrated. Recrystallization in EtOAc/hexanes give the title compound (870 mg). (ES) m/z 182 [M+H]+; 204 [M+Na]+.

1. customTo a pressure reaction flask
2. customIt was sealed
3. temperaturecooled to RT
4. concentrationThe reaction mixture was concentrated
5. dissolutiondissolved in EtOAc
6. washwashed with water
7. dry with materialdried over Na2SO4
8. concentrationconcentrated
9. customRecrystallization in EtOAc/hexanes