Potassium Carbonate → 1-(Diphenylmethyl)-4-[(oxiran-2-yl)methyl]piperazine

HRID 1518945Notes

Reaction equation

HRID 1518945 reaction equation
[C:1]1([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:26]([CH:28]1[O:30][CH2:29]1)Br>CC(C)=O>[C:14]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]2[CH2:9][CH2:10][N:11]([CH2:26][CH:28]3[O:30][CH2:29]3)[CH2:12][CH2:13]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18430EpibromohydrinHCID 70048Benzhydrylpiperazine

Product 1

HCID 102447781-(Diphenylmethyl)-4-[(oxiran-2-yl)methyl]piperazine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In acetone, 1-(diphenylmethyl)piperazine (6.0 g) was dissolved (20 v/w), and potassium carbonate (1.5 eq.) and epibromohydrin (2.0 eq.) were added thereto, and the obtained mixture was heated to reflux for 3.5 hours. The salt produced by the reaction was separated by filtration, and the filtrate was then concentrated in vacuo to obtain a crude product of 1-(diphenylmethyl)-4-(1-(2,3-epoxy)propyl)piperazine.

Workup

  1. additionwere added
  2. temperaturethe obtained mixture was heated
  3. temperatureto reflux for 3.5 hours
  4. customThe salt produced by the reaction
  5. customwas separated by filtration
  6. concentrationthe filtrate was then concentrated in vacuo

Sources & evidence

ORD record
ord-33df804b83274acea3dc68a46b71316a
Source dataset
uspto-grants-2015_07
Patent number
US09073861B2

Reaction notes

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