反应详情

methyl-1-(2-nitrophenylsulfonamido)cyclobutanecarboxylate (500 mg, 1.59 mmol) was charged and dissolved through addition of THF (5 ml), and methanol (5 ml). LiOH.H2O dissolved in H2O (5 ml) was added thereto, followed by stirring for 12 hours at room temperature. After the stirring for 12 hours, the resultant solution was vacuum-evaporated, acidified with 2N—HCl to pH 2-3, and extracted with EA (×2). The organic layer was dried with MgSO4, and filtered. Then, through vacuum distillation, the solvent was removed so as to obtain methyl-1-(2-nitrophenylsulfonamido)cyclobutanecarboxylic acid (468 mg, 1.56 mmol, 98%).

1. additionwas added
2. waitAfter the stirring for 12 hours
3. customthe resultant solution was vacuum-evaporated
4. extractionextracted with EA (×2)
5. dry with materialThe organic layer was dried with MgSO4
6. filtrationfiltered
7. distillationThen, through vacuum distillation
8. customthe solvent was removed so as