反应详情

温度

60 °C

A mixture of 2-cyclopropyl piperazine (50 mg, 0.40 mmol), 1-(2-bromoethyl)-4-nitrobenzene (360 mg, 1.6 mmol), tetrabutylammonium iodide (15 mg, 0.16 mmol), and K2CO3 (220 mg, 1.6 mmol) in DMF (2 mL) was heated to 60° C. for 16 hours. LC showed formation of the desired product, which was separated by mass-directed HPLC. LC-MS (IE, m/z): 425 [M+1]+. (0.86 μm)