反应详情

To a flask charged with 5-(2-piperazin-1-ylethyl)-2,1,3-benzoxadiazole hydrochloride (25 mg, 0.093 mmol) and a stir bar was added 6-(1H-tetrazol-1-yl)-3,4-dihydronaphthalen-2(1H)-one (30 mg, 0.14 mmol), Titanium (IV) isopropoxide (0.27 mL, 0.93 mmol), and sodium cyanoborohydride (29 mg, 0.46 mmol). The mixture was allowed to stir for 3 hours. LC showed formation of the desired product. The reaction was diluted with EtOAc, washed with brine, dried over sodium sulfate, filtered, concentrated and purified by mass-directed HPLC (0.1% TFA in water and acetonitrile). LC-MS (IE, m/z): 431 [M+1]+. (0.98 μM)