反应详情

To a mixture of piperazine (13 mg, 0.15 mmol) and 5-fluoro-2-methoxy-4-(2-oxoethyl)benzonitrile (58 mg, 0.30 mmol) in methanol (3.0 mL) at 0° C. was added sodium cyanoborohydride (24 mg, 0.38 mmol) and the mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated and purified by mass-directed HPLC to provide 4,4′-(piperazine-1,4-diyldiethane-2,1-diyl)bis(5-fluoro-2-methoxybenzonitrile). LC-MS (IE, m/z): 441.4 [M+1]+. (0.34 μM)

1. concentrationThe reaction mixture was concentrated
2. custompurified by mass-directed HPLC