Trifluoroacetic acid → HCID 67514674, compound

HRID 1519623Notes

Reaction equation

HRID 1519623 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH:12]2[C:24]([F:27])([F:26])[F:25])=[CH:5][C:4]=1[O:28][CH3:29])#[N:2].FC(F)(F)C(O)=O>ClCCl>[CH3:29][O:28][C:4]1[CH:5]=[C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH:12]2[C:24]([F:26])([F:27])[F:25])[CH:7]=[CH:8][C:3]=1[C:1]#[N:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86694485HCID 86694485, compound

Product 1

HCID 67514674HCID 67514674, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 4-[2-(4-cyano-3-methoxyphenyl)ethyl]-3-(trifluoromethyl)piperazine-1-carboxylate (116 mg, 0.282 mmol) in dichloromethane (2 mL) was treated with trifluoroacetic acid (1 mL) and stirred at room temperature for 2 hours. The reaction mixture was concentrated to provide 2-methoxy-4-{2-[2-(trifluoromethyl)piperazin-1-yl]ethyl}benzonitrile. LC-MS (IE, m/z): 314.4 [M+1]+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-2ba2a8585b804e21a638ba122d8a0573
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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