HRID1519675

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

结构：CNC(=O)C(C(=O)NO)N(C)C(=O)c1ccc(-c2ccc(OCCCN3CCOCC3)cc2)cc1

HCID86679255

未命名化合物

2 次

PRODUCTS

生成物

结构：CNC(=O)C(C(=O)NO)N(C)C(=O)c1ccc(-c2ccc(OCCCN3CCOCC3)cc2)cc1.Cc1ccc(S(=O)(=O)O)cc1

HCID86679256

未命名化合物

收率 79.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To a THF (1.0 mL) suspension of N-hydroxy-N′-methyl-2-[methyl({4′-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}carbonyl)amino]propanediamide (Compound 7, 24 mg) as obtained in Example 4-(5), p-TsOH.H2O (9.5 mg) was added, and the mixture was stirred for 10 minutes at room temperature. The precipitate was collected by filtration to obtain N-hydroxy-N′-methyl-2-[methyl({4′-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}carbonyl)amino]propanediamide 4-methylbenzenesulfonate (Compound 7b, white solid) (26 mg, 79%).

WORKUP

后处理

filtrationThe precipitate was collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6026e1eaffdf42f3a463b598d1ea8dff
来源数据集: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09073821B2
来源说明: uspto-grants-2015_07

反应 SMILES

[OH:1][NH:2][C:3](=[O:35])[CH:4]([N:9]([CH3:34])[C:10]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)=[O:11])[C:5]([NH:7][CH3:8])=[O:6].[CH3:36][C:37]1[CH:38]=[CH:39][C:40]([S:43]([OH:46])(=[O:45])=[O:44])=[CH:41][CH:42]=1.O>C1COCC1>[CH3:36][C:37]1[CH:38]=[CH:39][C:40]([S:43]([OH:46])(=[O:45])=[O:44])=[CH:41][CH:42]=1.[OH:1][NH:2][C:3](=[O:35])[CH:4]([N:9]([CH3:34])[C:10]([C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:20][CH:19]=2)=[CH:16][CH:17]=1)=[O:11])[C:5]([NH:7][CH3:8])=[O:6]