2-Amino-4-methylthiophene-3-carboxamide → HCID 68786937, compound

HRID 1519780Notes

Reaction equation

HRID 1519780 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=O)=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[NH2:19][C:20]1[S:21][CH:22]=[C:23]([CH3:28])[C:24]=1[C:25]([NH2:27])=[O:26]>C(N(CC)CC)C>[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][C:16]([NH:19][C:20]3[S:21][CH:22]=[C:23]([CH3:28])[C:24]=3[C:25]([NH2:27])=[O:26])=[O:18])=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 2938102-Amino-4-methylthiophene-3-carboxamideHCID 13569193HCID 13569193, compound

Product 1

HCID 68786937HCID 68786937, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

This compound was prepared from 2-(4-(2-(1H-imidazol-1-yl)ethoxy)phenyl)acetic acid and 2-amino-4-methylthiophene-3-carboxamide using protocol B except that triethylamine was also added. The crude product was purified via silica gel column chromatography. Method[1], MS(ESI) 385.1, Retention time=1.254 min.

Workup

  1. additionwas also added
  2. customThe crude product was purified via silica gel column chromatography

Sources & evidence

ORD record
ord-4a3294dbb7b3419d906adb01da7303c1
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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