反应详情

To a mixture of (4′-chlorobiphenyl-4-yl)(cyclohexyl)methanone (792.1 mg), THF (5.68 mL) and methanol (0.947 mL) was added sodium borohydride (120 mg) at 0° C. The reaction mixture was stirred at room temperature for 2 hr, and saturated aqueous sodium hydrogen carbonate solution was added at 0° C. The mixture was extracted with ethyl acetate, and the extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound as a crudely purified product. This compound was used in step C without further purification.

1. extractionThe mixture was extracted with ethyl acetate
2. washthe extract was washed with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated under reduced pressure