Hydrochloric Acid → HCID 86674814, compound

HRID 1520786Notes

Reaction equation

HRID 1520786 reaction equation
[Cl:1][C:2]1[C:3]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([C@@H:22]4[O:27][CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23]4)=[CH:18][CH:17]=3)=[O:14])=[N:9]2)=[N:4][CH:5]=[CH:6][N:7]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:3]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([NH:15][C:16]3[CH:17]=[CH:18][C:19]([C@@H:22]4[O:27][CH2:26][CH2:25][NH:24][CH2:23]4)=[CH:20][CH:21]=3)=[O:14])=[N:9]2)=[N:4][CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86674813HCID 86674813, compound

Product 1

HCID 86674814HCID 86674814, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
60 °C

Procedure

(S)-tert-Butyl 2-(4-(1-(3-chloropyrazin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate (44 mg, 90.7 μmol) was dissolved in dioxane (0.35 ml) and a solution of HCl in dioxane (340 μl, 1.36 mmol) was added and the reaction mixture was stirred at 60° C. for 90 min.

Sources & evidence

ORD record
ord-88e0c76f68f74b619e24ca3272a0be55
Source dataset
uspto-grants-2015_07
Patent number
US09073911B2

Reaction notes

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