反应详情

温度

100 °C

To 3,5-dibromo-4-(1H)-pyridone (W, 1.0 g, 3.97 mmol) was added phosphorous oxychloride (5 mL) and the mixture was heated at 100° C. for 2 h. The mixture was poured into ice/water (25 g) and basified by the addition of a saturated solution of sodium hydrogen carbonate. The mixture was extracted with dichloromethane (2×20 mL), the combined organic extracts were washed with saturated aqueous sodium chloride solution (25 mL), dried over sodium sulphate and concentrated under vacuum to obtain the title compound. MS (M+1): 271.8.

1. extractionThe mixture was extracted with dichloromethane (2×20 mL)
2. washthe combined organic extracts were washed with saturated aqueous sodium chloride solution (25 mL)
3. dry with materialdried over sodium sulphate
4. concentrationconcentrated under vacuum