Sodium Hydroxide → 1-(5-Bromopyridin-3-yl)cyclopropane-1-carboxylic acid

HRID 1521608ノート

反応式

HRID 1521608 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]([O:13]C)=[O:12])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1.[OH-].[Na+]>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]([OH:13])=[O:12])[CH2:9][CH2:10]2)[CH:5]=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59578399Methyl 1-(5-bromopyridin-3-yl)cyclopropanecarboxylate

生成物 1

HCID 595784161-(5-Bromopyridin-3-yl)cyclopropane-1-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the title compound from Example 71 Step B (100 mg, 0.390 mmol) in tetrahydrofuran (2.0 mL) was added aqueous 1 N sodium hydroxide solution (0.390 ml, 0.390 mmol). After stirring for several hours at room temperature, the reaction was concentrated under reduced pressure to provide the title compound: LCMS m/z 241.95 [M+H]+; 1H NMR (500 MHz, CDCl3) δ 8.58 (s, 1H), 8.53 (s, 1H), 7.86 (s, 1H), 1.76-1.74 (m, 2H), 1.29-1.27 (m, 2H).

後処理

  1. concentrationthe reaction was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-648105d497004480bec1574cbfef96a3
出典データセット
uspto-grants-2015_07
特許番号
US09073929B2

反応ノート

読み込み中…