Potassium Carbonate → HCID 90408481, compound

HRID 1521682Notes

Reaction equation

HRID 1521682 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2=[CH:9][NH:10][N:11]=[C:5]2[N:4]2[CH2:12][C:13]([CH3:16])([CH3:15])[N:14]=[C:3]12.Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25](=[O:27])[CH3:26])=[CH:21][CH:20]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([CH2:18][N:10]2[CH:9]=[C:6]3[C:7](=[O:8])[N:2]([CH3:1])[C:3]4[N:4]([CH2:12][C:13]([CH3:16])([CH3:15])[N:14]=4)[C:5]3=[N:11]2)=[CH:20][CH:21]=1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 5837851-[4-(Bromomethyl)phenyl]ethan-1-oneHCID 178481350HCID 178481350, compound

Product 1

HCID 90408481HCID 90408481, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A suspension of 7,8-dihydro-5,7,7-trimethyl-[2H]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one (438 mg, 2.0 mmol), 1-(4-(bromomethyl)phenyl)ethanone (520 mg, 2.4 mmol) and K2CO3 (828 mg, 6.0 mmol) in DMF (18 mL) is stirred at room temperature over a weekend. Solvent is removed under reduced pressure. The obtained residue is purified on a basic alumina oxide column to give 634 mg of product (yield: 90%). MS (ESI) m/z 352.2 [M+H]+.

Workup

  1. customSolvent is removed under reduced pressure
  2. customThe obtained residue is purified on a basic alumina oxide column

Sources & evidence

ORD record
ord-e6c26dc661654e5986dae09cf5c9b0d2
Source dataset
uspto-grants-2015_07
Patent number
US09073936B2

Reaction notes

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