反应详情

To a solution of propanenitrile (5 g, 94 mmol) in ethanol at 0° C. is added hydrazine hydrate (4.6 g, 91 mmol), dropwise. The reaction mixture is stirred at ambient temperature for 16 h after. The mixture is cooled to 0° C. and tetrahydropyran-4-one (9 g, 90 mmol) is added slowly. The reaction continues to stir at ambient temperature for an additional 5 h. The solvent is evaporated under reduced pressure to afford the title compound as a highly viscous liquid (15 g, >99%) which is used in the next step without purification.

1. temperatureThe mixture is cooled to 0° C.
2. stirringto stir at ambient temperature for an additional 5 h
3. customThe solvent is evaporated under reduced pressure