Morpholine → HCID 68228689, compound

HRID 1521827Notes

Reaction equation

O([C:8]([NH:10][C:11]1[CH:12]=[C:13]([N:17]2[C:21]3[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=4[S:28](=[O:31])(=[O:30])[CH2:29][C:20]=3[C:19]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[N:18]2)[CH:14]=[CH:15][CH:16]=1)=[O:9])C1C=CC=CC=1.[NH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1.C(N(CC)CC)C>CN1CCCC1=O.O>[N:37]1([C:8]([NH:10][C:11]2[CH:12]=[C:13]([N:17]3[C:21]4[C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=5[S:28](=[O:31])(=[O:30])[CH2:29][C:20]=4[C:19]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[N:18]3)[CH:14]=[CH:15][CH:16]=2)=[O:9])[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1

Participants

Conditions

Temperature: 55 °C

Procedure

A mixture of ethyl 1-{3-[(phenoxycarbonyl)amino]phenyl}-1,4-dihydrothiochromeno[4,3-c]pyrazole-3-carboxylate 5,5-dioxide (100 mg, 0.198 mmol), morpholine (0.03 mL, 0.3 mmol), triethylamine (0.03 mL, 0.3 mmol) in N-methyl-2-pyrrolidone is heated under microwave irradiation for 15 min at 55° C. The reaction mixture is diluted with water and is stirred for another hour. The precipitate is filtered and dried under vacuum to afford 80 mg (81%) of the title compound. MS (ESI+): 497.2.

Workup

filtrationThe precipitate is filtered
customdried under vacuum

Sources & evidence

ORD record: ord-87d36a31b7994cccaa0e4a0a7c07df34
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09073940B2

Reaction notes

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