反应详情

温度

80 °C

7-Iodo-1H-pyrazolo[4,3-b]pyridine (50 mg, 0.204 mmol), bromomethylcyclopropane (27.5 mg, 0.204 mmol) and cesium carbonate (133 mg, 0.408 mmol) in DMF (1.0 mL) were heated in a microwave at 80° C. for 15 minutes. Additional bromomethylcyclopropane (27.5 mg, 0.204 mmol) was then added and the reaction was further heated in a microwave at 80° C. for 30 minutes. The reaction was cooled and poured into water (10 mL) and extracted with ethyl acetate (5 mL). The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo to give 1-(cyclopropylmethyl)-7-iodo-1H-pyrazolo[4,3-b]pyridine and 2-(cyclopropylmethyl)-7-iodo-2H-pyrazolo[4,3-b]pyridine as a mixture (60/40); MS [M+H] found 300.1.

1. temperatureThe reaction was cooled
2. extractionextracted with ethyl acetate (5 mL)
3. dry with materialThe organic layer was dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo