Carbon Dioxide → HCID 86674679, compound

Temperature

0 °C

To a flame-dried round-bottomed flask equipped with two dropping funnels was added iPr2NH (2.5 equiv, 71.4 mmol, 7.22 g, 10.0 mL) and THF (225 mL) and the solution was cooled to 0° C. nBuLi (2.5 equiv, 71.4 mmol, 44.6 mL of a nominally 1.6 M solution in hexanes) was added dropwise and the reaction was stirred for 30 min at 0° C. nBu3SnH (2.3 equiv, 65.6 mmol, 19.1 g, 17.7 mL) was added dropwise and the reaction was stirred for 30 min at 0° C. The reaction was cooled to −50° C. by the controlled addition of dry ice to acetone and CuCN (2.3 equiv, 65.6 mmol, 5.88 g) was added in one portion. The reaction was stirred for 45 min at −50° C. then cooled to −78° C. MeOH (1.70 mL) was added followed by the addition of methyl-11-[(tetrahydro-2H-pyran-2-yl)oxy]-undecynoate (1 equiv, 28.5 mmol, 8.46 g) in THF (85 mL) in one portion. The reaction was stirred at −78° C. for 10 min, then quenched with 170 mL of aq. NH4Cl/NH4OH (pH ˜8) and diluted with 150 mL Et2O. The reaction was warmed to rt (orange color is discharged and solution turns colorless), the layers were separated, and the aqueous layer extracted with Et2O (3×120 mL). The combined organic layers were washed with aq. NH4Cl/NH4OH (pH ˜8) (100 mL), and brine (120 mL), dried with Na2SO4, concentrated in vacuo, and purified by flash column chromatography (step gradient, Hex to 5% EtOAc/Hex) to afford (E)-methyl 11-((tetrahydro-2H-pyran-2-yl)oxy)-3-(tributylstannyl)undec-2-enoate (15.1 g, 25.5 mmol, 90%). TLC Rf=0.30 (5% EtOAc/Hex); 1HNMR (500 MHz): δ 5.86-6.03 (m, 1H), 4.56-4.62 (m, 1H), 3.85-3.92 (m, 1H), 3.74 (dt, 1H, J1=9.6 Hz, J2=6.9 Hz), 3.70 (s, 3H), 3.47-3.54 (m, 1H), 3.39 (dt, 1H, J1=9.6 Hz, J2=6.7 Hz), 2.78-2.97 (m, 2H). 1.79-1.90 (1H), 1.69-1.77 (1H), 1.27-1.65 (29H), 0.93-0.99 (5H), 0.91 (t, 9H, J=7.3 Hz); 13CNMR (125 MHz): δ 174.9, 164.6, 127.0, 98.8, 67.7, 62.3, 50.8, 35.3, 30.8, 29.8, 29.77, 29.68, 29.5, 29.0, 27.4, 26.3, 25.5, 19.7, 13.7, 10.0; FTIR: 2918, 2852, 1717, 1591, 1456, 1431, 1351, 1189, 1162, 1136, 1121, 1077, 1022, 867 cm−1; HRMS-ESI: calc. for C29H56NaO4Sn (M+Na)+: 611.3104. found: 611.3111.

1. customTo a flame-dried round-bottomed flask equipped with two dropping funnels
2. additionwas added dropwise
3. additionwas added dropwise
4. additionwas added in one portion
5. stirringThe reaction was stirred for 45 min at −50° C.
6. temperaturethen cooled to −78° C
7. stirringThe reaction was stirred at −78° C. for 10 min
8. customquenched with 170 mL of aq. NH4Cl/NH4OH (pH ˜8)
9. additiondiluted with 150 mL Et2O
10. temperatureThe reaction was warmed to rt (orange color is discharged and solution turns colorless)
11. customthe layers were separated
12. extractionthe aqueous layer extracted with Et2O (3×120 mL)
13. washThe combined organic layers were washed with aq. NH4Cl/NH4OH (pH ˜8) (100 mL), and brine (120 mL)
14. dry with materialdried with Na2SO4
15. concentrationconcentrated in vacuo
16. custompurified by flash column chromatography (step gradient, Hex to 5% EtOAc/Hex)

ORD record

ord-919b90b448a743d5aaa6829a5db920f2

Source dataset

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09079835B2