反应详情

5-(methylthio)-2-aminopyridine (185 g) was dissolved in 2 L tetrahydrofuran, and then 500 mL titanate tetraisopropyl and benzaldehyde (155 g) were added. The reaction mixture was heated for reflux overnight, then cooled to room temperature, and 10 L water was added. The reaction mixture was extracted with ethyl acetate, the organic phase was washed with saturated NaCl solution, and dried with anhydrous sodium sulfate. After filtration, the residual solution was removed under reduced pressure to obtain the target compound (200 g).

1. temperatureThe reaction mixture was heated
2. temperaturefor reflux overnight
3. extractionThe reaction mixture was extracted with ethyl acetate
4. washthe organic phase was washed with saturated NaCl solution
5. dry with materialdried with anhydrous sodium sulfate
6. filtrationAfter filtration
7. customthe residual solution was removed under reduced pressure